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Immediately after the operation, 2.5 mL polyacrylamide hydrogel (Noltrex, Bioform, Moscow, Russia) was injected with standard approach to the knees in order to diminish the cartilage damage. After injection, in first 24 hours, classical inflammatory responses, tumor, dolor, rubor, calor, and functio laesa, were observed in the right knee.
The cationic copolymers usually have no more than 5% of cationic groups due to FDA limits for paper products that may contact food. The anionic copolymers also can be prepared by an alternative route, partial hydrolysis of the amide groups after synthesis of the polyacrylamide homopolymer.