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A wet strength resin having synergistic properties consists of a polymer of glyoxal, acrylamide, formaldehyde and urea. The formaldehyde, urea, glyoxal and acrylamide are present in the following mole ratios: formaldehyde to urea, from about 1:1 to about 5:1; formaldehyde to urea and acrylamide, from about 0.25:1 to about 2.5:1 and glyoxal to acrylamide of from about 0.2:1 to about 1.14:1.
