synthesis of super-high molecular weight polyacrylamides in britain
Although agarose and agarose-polyacrylamide gels were used for separation of RNA and single-stranded DNA in the late 1960s [15,16], the work to analyze restriction-digested fragments by agarose gel electrophoresi s was not published until 1973 (Figure 3) [17,18].
Electrophoresis with agarose and polyacrylamide gels is one of the most widely used tools in molecular biology. Gels provide a simple, low-cost way to separate nucleic acids based on size for quantification and purification. The basics. Agarose gels can be used to resolve large fragments of DNA.