in vitro degradation of medical polyacrylamide hydrogel at malaysia

in vitro degradation of medical polyacrylamide hydrogel at malaysia
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  • Can polyacrylamide-based hydrogel coatings improve device function and lifetime?
  • These polyacrylamide-based copolymer hydrogel coatings have the potential to improve device function and lifetime, thereby reducing the burden of disease management for people regularly using implanted devices. Doreen Chan and Eric A. Appel are listed as authors on a provisional patent application describing the technology reported in this article.
  • How are polyacrylamide-based hydrogels obtained?
  • Polyacrylamide-based hydrogels were obtained by chemical crosslinking of MBA using acrylamide, sodium carboxymethylecellulose (NaCMC), N,N,N ′, N ′-tetramethylethylenediamine (TEMED) and ammonium persulfate (APS) as the initiators.
  • What is a polyacrylamide hydrogel?
  • Polyacrylamide is a well-known hydrogel whose swelling capacity is not very sensitive to pH or electrolytes. Polyacrylamide hydrogels are usually synthesized in aqueous solution using water-soluble initiators and crosslinking agents such as N,N ′-methylenebisacrylamide [5, 17].
  • Are polyacrylamide-based copolymer hydrogels biocompatible?
  • We prepared a library of polyacrylamide-based copolymer hydrogels, which were selected from materials previously shown to exhibit remarkable antifouling properties with blood and plasma, and implanted them into the subcutaneous space of mice to evaluate their biocompatibility over the course of 1 month.